I've recorded a video which will show you the new vSphere 5 iSCSI UI support and some other usability improvements. In vSphere 5 you'll have the ability to configure dependent hardware iSCSI and software iSCSI adapters along with the network configurations and port binding in a single dialog box using the vSphere Client. Full SDK access is also available for these configurations.
If you use the software or dependent hardware iSCSI adapters, you must configure connections for the traffic between the iSCSI component and the physical network adapters. Configuring the network connection involves creating a virtual VMkernel interface for each physical network adapter and associating the interface with an appropriate iSCSI adapter.
If your host has more than one physical network adapter for software and dependent hardware iSCSI, use the adapters for multipathing. You can connect the software iSCSI adapter with any physical NICs available on your host. The dependent iSCSI adapters can be connected only with their own physical NICs.