I’ve created a real cool video which shows you how to configure your vSphere 5 network in order to use multiple network adapters for vMotion. The idea for this video came from fellow VCI and virtualization friend Frank Brix Pedersen. More information about vMotion Architecture, Performance, and Best Practices in VMware vSphere 5 can be found here.
When using the multiple–network adaptor feature, configure all the vMotion vmnics under one vSwitch and create one vMotion vmknic for each vmnic. In the vmknic properties, configure each vmknic to leverage a different vmnic as its active vmnic, with the rest marked as standby. This way, if any of the vMotion vmnics become disconnected or fail, vMotion will transparently switch over to one of the standby vmnics. When all your vmnics are functional, though, each vmknic will route traffic over its assigned, dedicated vmnic.